9/22/2023 0 Comments Antigenic fragment definitionThe endogenous pathway is used to present cellular peptide fragments on the cell surface on MHC class I molecules. While the joint distinction between the two pathways is useful, there are instances where extracellular-derived peptides are presented in the context of MHC class I and cytosolic peptides are presented in the context of MHC class II (this often happens in dendritic cells). proteolysis of antigens for binding to MHC I molecules). Cross-presentation involves parts of the exogenous and the endogenous pathways but ultimately involves the latter portion of the endogenous pathway (e.g. MHC I antigen presentation typically (considering cross-presentation) involves the endogenous pathway of antigen processing, and MHC II antigen presentation involves the exogenous pathway of antigen processing. Both MHC class I and II are required to bind antigens before they are stably expressed on a cell surface. bacteria) subsequent presentation of these antigens on class I or class II major histocompatibility complex (MHC) molecules is dependent on which pathway is used. viruses), or from phagocytosed pathogens (e.g. This process involves two distinct pathways for processing of antigens from an organism's own (self) proteins or intracellular pathogens (e.g. It is considered to be a stage of antigen presentation pathways. Antigen processing, or the cytosolic pathway, is an immunological process that prepares antigens for presentation to special cells of the immune system called T lymphocytes.
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